The fruit of the Mid-Autumn Festival is grapefruit, but people who take blood lipid-lowering and blood pressure-lowering drugs should be reminded to pay attention! Avoid taking grapefruit Wendan while taking the medicine, otherwise there will be adverse effects! Experts also pointed out that don't think that eating separately will be fine. Eating separately will only reduce the chance of side effects, and it will never be zero.
Schematic／
Toxicology expert Zhao Mingwei pointed out in Fanzhuan that most people know that people who take blood lipid-lowering and blood pressure-lowering drugs should avoid taking grapefruit at the same time, but everyone knows that grapefruit actually contains the same "grapefruit" Furanocoumarin (Furanocoumarin)” component, which irreversibly inhibits the function of metabolic enzyme CYP450 3A4 in the small intestine and liver by at least 50%.
However, since "many drugs are metabolized by this enzyme", furanocoumarin will form an irreversible covalent bond with CYP450 3A4, resulting in the stagnation of the function of the enzyme. At the same time, the drug cannot be metabolized, resulting in a significant increase in the concentration of the drug in the blood, but it cannot be excreted from the body in a short time. The chance of toxicity is greatly increased.”
Zhao Mingwei explained that, taking Statin drugs as an example, they must be metabolized by the enzyme CYP450 3A4 before they can be excreted from the body after achieving their effect; but Statin drugs are HMG-CoA reductase enzymes. inhibitor,It is a drug specially used for lowering blood lipids and cholesterol. It has been used for many years. Its derivatives include Atorvastatin, Cerivastatin, Fluvastatin, Pravastatin and Posuvastatin, among which there are similar drugs such as Fibrates. Cerivastatin can cause adverse reactions to muscle damage, and the rest of the products are quite popular all over the world. Therefore, if there are no special complications in patients with three highs, they will generally take prescription drugs like Statin.
In addition, Zhao Mingwei emphasized that some documents were specially mentioned, so Zhao Mingwei reminded the public not to think that as long as you eat separately or only drink grapefruit juice, it doesn't matter, wrong! In addition to not taking grapefruit at the same time as statin drugs, eating it separately only reduces the chance of side effects, and it will never be zero.
Zhao Mingwei explained the effect of grapefruit juice on the enzyme CYP450 3A4. The literature found that grapefruit juice can inhibit CYP450 3A4 for more than 24 hours. If you only drink a glass of grapefruit juice of 250 ml, at least It also takes 3 days to fully restore the enzyme activity in the gut.
Zhaomingwei also reminded,
In conclusion, the concomitant use of grapefruit and grapefruit with certain drugs may increase the risk of adverse drug reactions, such as certain blood pressure lowering drugs, statins hypolipidemic drugs, antiarrhythmic drugs, immunosuppressive drugsPreparations, etc., Zhao Mingwei reminds that if you are using these drugs, avoid eating grapefruit products; if you are already taking grapefruit, please read the copy of the drug or consult a pharmacist to confirm whether there is a risk of drug interaction. Seek immediate medical attention if you have unusual symptoms.
◎ Image source/Provided by Dazhi Image/shutterstock
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